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Effects of alcohol and aging on ERAD and tumorigenesis pathways. ERα, estrogen receptor α variants (ERα36, 46, and 66); p-ERK1/2, phosphorylated extracellular signal-regulated protein kinases 1 and 2; p-STAT3, phosphorylated signal transducers and activators of transcription; MW, middle-aged WT; MK, middle-aged KO; OW, older WT; OK, older KO; OKL, the liver portion of tumor bearing livers of older KO; OKT, the tumor portion of tumor bearing livers of older KO.
