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. 2013 Oct 31;7:190. doi: 10.3389/fncel.2013.00190

Figure 1.

Figure 1

Molecular signaling pathways for NO. The main signaling pathways described in the text for NOS1 are shown together with their effector molecules. NO has three main routes of action via nitrosothiol production, cGMP and PKG. Abbreviations: NOS1, Nitric Oxide Synthase 1; NO, Nitric Oxide; sGC, soluble guanylate cyclase; PKG, protein kinase G; G-substrate, a phosphatase inhibitor; BKCa, large calcium sensitive potassium channel; Ca2+N, N-type calcium channel; PIP2, phosphotidylinositol 4,5 biphosphate; VASP, vasodilator stimulated phosphoprotien; CNG, cyclic nucleotide gated channel; HCN, hyperpolarization-activated, cyclic nucleotide-modulated channel; Munc18, also known as Sec-1, is a pre-synaptic SNARE associated protein; syntaxin 1A, part of the SNARE complex; NR1, NMDA receptor subunit 1; NR2, NMDA receptor subunit 2; NSF, N-ethylmaleimide sensitive fusion protein. There is evidence for nitrosothiol production in NSF, NR1, and NR2 in vivo, but endogenous production of nitrosothiol groups in syntaxin requires confirmation.