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. 2013 Oct 31;7:190. doi: 10.3389/fncel.2013.00190

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Copyright © 2013 Hardingham, Dachtler and Fox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of NO on the frequency of GABAergic spontaneous IPSCs (sIPSCs). (A) Plot of the peak amplitudes of spontaneous IPSCs against time for a thalamocortical (TC) lateral geniculate neuron. At the time indicated by the gray panel a switch is made from voltage to current clamp so that somatic action potentials can be generated. Note the increase in sIPSCs on returning to voltage clamp and the block of all sIPSCs by SR95531 toward the end of the experiment. (B) A similar recording from a TC relay neuron with the same protocol as in (A), but in the presence of the NO scavenger PTIO (20 μ M) in the external solution. Note that GABAergic synaptic plasticity is blocked. Adapted from Bright and Brickley (2008) with kind permission of the authors and the Physiological Society.