Table 2.

The role of Nitric oxide in GABAergic function.

References	Title	Presynaptic action?	Retrograde messenger?	Effect?	Structure (preparation)
Lange et al., 2012	Heterosynaptic long-term potentiation at interneuron-principal neuron synapses in the amygdala requires nitric oxide signaling	✓	✓	Effect on plasticity	Amygdala (slice)
Moreno-Lopez et al., 2002	Nitric oxide facilitates GABAergic neurotransmission in the cat oculomotor system: a physiological mechanism in eye movement control	✓	✓	Controls velocity responsiveness of PH neurons	Medial vestibular nucleus projection to prepositus hyperglossi (PH) neurons (in vivo)
Szabadits et al., 2007	Hippocampal GABAergic synapses possess the molecular machinery for retrograde nitric oxide signaling	✓	✓	Anatomical evidence: nNOS is post and sCG presynaptic	Hippocampus (in vivo)
Xue et al., 2011	NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms	✓	✓	Increase in sIPSP frequency and amplitude	Hippocampal (slice)
Yang et al., 2007	Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus	✓	✓	Nitric oxide acts on GABA via Kv1.1/1.2	Paraventricular nucleus of the hypothalamus (slices)
Yang et al., 2007	Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus	✓	✓	Increases frequency but not amplitude of inhibitory minis	Paraventricular nucleus of the hypothalamus (slices)
Bright and Brickley, 2008	Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus	✓	✓	Increases frequency of sIPSCs	Thalamus (slices)
Wall, 2003	Endogenous nitric oxide modulates GABAergic transmission to granule cells in adult rat cerebellum	✓	✓	NO modulates toninc GABA release	Cerebellum (slices)
Holmgren and Zilberter, 2001	Coincident spiking activity induces long-term changes in inhibition of neocortical pyramidal cells			Analogous to cases where nitric oxide is involved	Neocortical (slices)