Multiple hybrid three-dimensional renderings of the 8-animal cohort at baseline. In each case, color contouring, which is determined by intercommissural two-dimensional leaflet curvatures, has been superimposed across a 1.0-mm-wide, intercommissurally oriented segment of the anterior leaflet. (A) This is a transvalvular (xy) view of the rendering. (B) The same view is illustrated where the posterior leaflet is transparent. (C) This panel illustrates an oblique view of the isolated anterior leaflet; in this case, the relationship between the curvature sign and surface concavity/convexity is readily apparent. The midanterior annulus (mid-AA), midposterior annulus (mid-PA) anterior commissure (AC), and posterior commissure (PC) have been labeled as appropriate.