Figure 3.

Verification of ion conductance sensitivity predictions. Steady-state AP and Ca²⁺ transients (recorded 9-10 s) in each of the three non-SR compartments in response to 1 Hz stimulus. The predicted changes in APD₆₀ and Ca²⁺ peaks (see Insets also) are consistent with the generated by Nimrod/E and PLS outputs with respect to 10% increases in transporters' conductance. Control conductance values (black solid line) and 10% increases in K _NCX (black dashed line), P _CaL (black dash-dot line), G _Kr (gray dash-dot line), G _to (gray solid line), K _NaK(gray dotted line), and G _ClBk (black dotted line).