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. 2013 Oct 7;2013:565431. doi: 10.1155/2013/565431

Figure 4.

Figure 4

Parameter sensitivity analysis of APD60, Δ[Ca]i, Δ[Ca]SL, and Δ[Ca]jct sensitivities toward 5% increases in ion transporter distributions in the junctional cleft. Transporters' distribution between sarcolemma and junctional cleft summed up to 100%. Increasing fraction of total j-current in the junction by 5% is analogous to decreasing fraction of total j-current in the subsarcolemma by 45% for I Ca and by 40-41% for all other currents. Positive value indicates direct relationship between distribution and output (e.g., increased density of I Ca in the junctional cleft shortens APD60) and negative value indicates indirect relationship between parameter and output. Nimrod/E-Lenth plots (left column), PLS-bar plots (right column). Nimrod/E analysis produced similar qualitative results as PLS analysis.