Figure 5.

Verification of transporter distribution sensitivity predictions. Steady-state model outputs (recorded 9-10 s) in response to 1 Hz periodic pulse. The predicted alterations in APD₆₀ and Ca²⁺ peaks (see Insets also) are consistent with the generated by Nimrod/E and PLS results with respect to 5% increases in transporters' fraction in the junctional cleft. Default j-currents' fractions in junctional cleft (black solid line) and 5% increases in Fx _CaL(jct) (black dashed line), Fx _Cl(Ca)(jct) (grey dotted line), Fx _NCX(jct) (black dash-dot line).