Figure 7.

Verification of Ca²⁺ and Na⁺ diffusion sensitivity predictions. Steady-state AP and Ca²⁺ transients (recorded 9-10 s) in three non-SR compartments in response to 1 Hz stimulus. The relative changes in APD₆₀ and Ca²⁺ peaks (see Insets also) are consistent with predictions generated by Nimrod/E and PLS with respect to 10% increases in Ca²⁺ and Na⁺ diffusion constants. Control diffusion coefficients (black solid line) and 10% increases in D _Ca(jct-SL) (black dashed line), D _Ca(SL-i) (black dash-dot line), D _Na(jct-SL) (gray dotted lines), D _Na(SL-i) (light gray dotted lines).