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One-electron redox cycle of anthracyclines. One-electron addition to the quinone moiety in the ring of carbon atoms of DOX and other anthracyclines result in the formation of a semiquinone that quickly regenerates its parent quinone by reducing oxygen to reactive oxygen species (ROS) like O2 •− and H2O2. ROS generated in redox cycle of anthracyclines induce oxidative DNA damage.
