Table 3.
Antibacterial activity and cytotoxicity of selected doxycycline neoglycosides
| Neoglycoside (see Figure 1) |
Sugar utilized |
E. coli 25922 (μg/mL) |
E. coli 1-849 (μg/mL) |
S. aureus R2507 (μg/mL) |
A549 viability (%) |
IMR 90 viability (%) |
|---|---|---|---|---|---|---|
| 4 | none | 4 | 8 | 4 | 95.9 | 99.2 |
| Dx26a | 2-deoxy-2-azido-D-glucose (21) | 4 | 4 | 4 | 99.1 | 94.6 |
| Dx15 | 2-deoxy-2-N-alloc-D-glucosamine (19) | 8 | 16 | 8 | 98.8 | 97.6 |
| Dx14 | forosamine (18) | 4 | 32 | 16 | 96.9 | 100.7 |
| Dx37 | 2-deoxy-2-N-trifluoroacetyl-D-glucosamine (37) | 4 | 32 | 16 | 98.7 | 109.1 |
| Dx23 | N-acetylmuramic acid (27) | 8 | 32 | 16 | 97.7 | 104.4 |
| Dx32 | 2-deoxy-2-azido-D-mannose (33) | 4 | 32 | 32 | 97.1 | 98.9 |
| Dx26b | 2-deoxy-2-azido-D-glucose (21) | 8 | 32 | 32 | 95.6 | 101.7 |
| Dx12 | D-arabinose (16) | 8 | 64 | 32 | 97.2 | 101.7 |
| Dx13 | D-erythrose (17) | 4 | 64 | 32 | 98.2 | 99.3 |