Table 3.
Cumulative 6-year incidence and hazard ratios of liver transplantation or liver-related death according to Ishak fibrosis stage and biopsy fragmentation
| Ishak Stage | ||||||
|---|---|---|---|---|---|---|
| 2 | 3 | 4 | 5 | 6 | ||
| Cumulative Incidence of transplant or death (N with outcomes) | p-value for trend |
|||||
| All biopsies | 4.3% (2) | 8.1 % (23) | 10.2 % (16) | 21.3 % (40) | 27.8% (45) | <0.0001 |
| Non- fragmented (NF) |
2.4% | 4.4% | 8.2% | 21.1% | 28.1% | <0.0001 |
| Fragmented (F) |
16.7% | 20.0% | 22.3% | 21.9% | 27.0% | 0.31 |
| F vs NF: HR* (95% CI) & p- value |
-- | 4.4 (1.9–10.1) 0.0004 |
2.4 (0.8–7.0) 0.10 |
1.1 (0.6–2.1) 0.83 |
0.9 (0.5–1.7) 0.79 |
-- |
*
Hazard ratio. Ishak 2 not compared because too few outcomes.