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. Author manuscript; available in PMC: 2013 Oct 31.
Published in final edited form as: J Control Release. 2011 Dec 2;160(2):10.1016/j.jconrel.2011.11.030. doi: 10.1016/j.jconrel.2011.11.030

Fig. 4.

Fig. 4

Cellular uptake of lipid–PEI–siRNA complexes. The uptake of lipid–PEI compounds complexed with Cy5-labled siRNA by HeLa cells was imaged using an Opera spinning disk confocal microscope. The uptake of the lipid:PEI mole ratio of 0.56 (A) is compared to that of lipid:PEI mole ratio of 2.91 (B). Five different representative images are presented for each compound (i–v) and image (vi) represents an enlarged image. Punctate structures can be noticed in panel A (vi), while cytoplasmic as well as punctuate structures can be seen in panel B (vi). Blue is Hoechst dye.