Fig 9. EUK-207 mitigates radiation induced loss of angiotensin converting enzyme (ACE) activity in the rat lung.
Experiment in WAGRijCmcr rats subjected to TBI (11 Gy) followed by BMT was conducted as described in the text and ACE activity was measured in isolated perfused lungs 6 wks after irradiation as described. Total lung ACE activity is represented as the mean surface area product [ml/min] based on a spectrophotometrically monitored substrate cleavage [53]. The data are means ± SEM, for n= 9 (No radiation), 7 (11 Gy), and 8 (11 Gy+EUK-207). * indicates significant difference from the 11 Gy group (one way ANOVA followed by Bonferroni’s t test).