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. Author manuscript; available in PMC: 2013 Oct 31.
Published in final edited form as: Curr Drug Targets. 2010 Nov;11(11):1423–1429. doi: 10.2174/1389450111009011423

Fig. 10.

Fig. 10

A normal glomerulus and its draining tubule (panel A) and one from a rat that underwent 18 Gy TBI in six fractions (panel B). The irradiated specimen shows periglomerular scarring that is accentuated at the glomerular-tubular junction (arrowhead), with narrowing of that junction, or neck, at that point. This neck stenosis can lead to complete closure and the formation of an atubular, non-filtering glomerulus. That evolution is stopped by captopril treatment. Adapted with permission of the Journal of Pathology, from Cohen et al. [39].