Skip to main content
. Author manuscript; available in PMC: 2013 Oct 31.
Published in final edited form as: Curr Drug Targets. 2010 Nov;11(11):1423–1429. doi: 10.2174/1389450111009011423

Fig. 5.

Fig. 5

Mitigation of radiation-induced azotemia (as BUN) 17 weeks after TBI plus BMT in a rat model. Data is shown as medians and ranges (n = 5–6 per group) for rats receiving TBI alone (●), TBI plus captopril at 17 mg/kg/day (○), or TBI plus losartan at 11 mg/kg/day (□). Drug therapy started 10 days after TBI and continued for 26 weeks. Two rats each in the captopril and losartan groups at 12.2 Gy were euthanized prior to 17 weeks because of high BUN levels. At 12.2 Gy, where rats were euthanized prior to 17 weeks because of high BUN levels, the medians assume infinite BUN values for those rats.