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IL-1b -stimulated HMGB1 release from astrocytes was attenuated by U0126 (10 μM) and LMB (20 nM). Values are means ± SEM of four independent experiments. *P<0.05, **P<0.01 compared with non-treated control, ##P<0.01 compared with IL-1b (100 pg/ml)-treated group.
