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. 2004 Mar 11;23(6):1313–1324. doi: 10.1038/sj.emboj.7600163

Figure 2.

Figure 2

TTP promotes the assembly of spontaneous SGs but is excluded from arsenite-induced SGs. (A) COS7 cells transiently transfected with TTP-myc were cultured in media alone, (B) treated for 90 min with FCCP (1 μM) or (C) treated for 60 min with arsenite (ARS, 0.5 mM). Cells were processed for dual label immunofluorescence using antibodies reactive with myc (left panels; red) and TIA-1 as a maker of SGs (center panels; green). (D) COS7 cells transiently transfected with GFP-TTP were cultured in media alone, (E) treated for 90 min with FCCP (1 μM) or (F) treated for 60 min with arsenite (ARS, 0.5 mM). GFP-TTP is visualized in green (left panels) and TIA-1 in red (center panels). Merged views are shown in the right panels. Arrows point out SGs; size bar is 10 μm.