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. Author manuscript; available in PMC: 2014 Oct 8.
Published in final edited form as: Structure. 2013 Aug 22;21(10):10.1016/j.str.2013.07.011. doi: 10.1016/j.str.2013.07.011

Figure 9. Principal component distributions for GluN2A and GluA2.

Figure 9

(A) 2D projection of apo GluN2A LBD conformers generated from umbrella sampling simulations onto the PC1–PC2 plane with W(ξ1, ξ2) < 1 and < 2 kcal mol−1 shown in blue and orange, respectively; 1D projections onto either PC1 or PC2 are represented by marginal histograms. (B) Projection of apo GluA2 conformers; the 2D projections of selected crystal structures are shown as yellow points. (C) Projection of GluN2A-glutamate conformers. (D) Projection of GluA2-glutamate conformers. See also Figure S4.