Table 1.
Optimisation of the coefficient of variation of phospho-Hsp27 particle numbers
| Reactions | Changes (no constraints) |
Changes (constraints) |
|---|---|---|
| complex + MKK6 ↔ complex_MKK6 | ⇒ | ⇒ |
| complex_MKK6 → complex + MKK6P | ⇒ | ⇒ |
| MKK6_phosphatase + MKK6P ↔ Ppase_MKK6P | ⇐ | ~ |
| Ppase_MKK6P → MKK6_phosphatase + MKK6 | ⇐ | ⇐ |
| complex + MKK3 ↔ complex_MKK3 | ⇒ | ⇒ |
| complex_MKK3 → complex + MKK3P | ⇒ | ⇒ |
| MKK3_phosphatase + MKK3P ↔ Ppase_MKK3P | ⇐ | ⇐ |
| Ppase_MKK3P → MKK3_phosphatase + MKK3 | ⇐ | ⇐ |
| MKK6P + p38 ↔ MKK6P_p38 | ⇒ | ⇒ |
| MKK6P_p38 → MKK6P + p38P | ⇒ | ⇒ |
| MKK3P + p38 ↔ MKK3P_p38 | ⇒ | ⇐ |
| MKK3P_p38 → MKK3P + p38P | ⇒ | ⇐ |
| p38_phosphatase + p38P ↔ Ppase_38P | ⇐ | ⇔ |
| Ppase_p38P → p38_phosphatase + p38 | ⇐ | ⇒ |
Optimisation of the coefficient of variation of phospho-Hsp27 particle numbers with regards to all 21 reaction parameters of the listed reactions ([LPS]0 = 1 ng/ml). "Changes (no constraints)" means that the coefficient was optimised without any further constraints, whereas "Changes (constrained)" means that during optimisation the phospho-Hsp27 particle number was constrained in the optimisation to stay below the limit of 4.65 million particles. "⇒" ("⇐") denotes an increase (decrease) in the forward rate and a decrease (increase) in the reverse rate, in case of a reversible reaction. "⇔" means that both forward and reaction rates are increased and "~" means that the optimisation led to no clear change