Skip to main content
. 2013 Oct 31;9(10):e1003890. doi: 10.1371/journal.pgen.1003890

Figure 9. ISO6-I304N FMRP is defective in its Cajal body association.

Figure 9

(A) GFP-ISO6-I304N displays reduced association with Cajal bodies. Note that not all coilin positive structures contain ISO6-I304N and that the majority of the ISO6-I304N remains nucleoplasmic. Arrowhead point to mini-ISO6-I304N positive Cajal bodies. (B) HeLa cells transiently transfected with the indicated GFP-fusion construct were used for FRAP experiments (as described in Material and Methods). (C) GFP-ISO6-I304N displays a faster turnover rate relative to wild type FMRP-ISO6.