Table 1. Prion disease in transgenic mice expressing different ovine PrP scrapie susceptibility alleles.
| Isolate | Genotype | Mean time to disease onset ± standard error of the mean (SEM), days1 | ||
| Tg(OvPrP-V136)4166+/− | Tg(OvPrP-A136)3533+/− | Tg(OvPrP-A/V) | ||
| 2 None | >552 (0/4) | >429 (0/5) | ||
| 2 SSBP/1 | A136/V136 | 132±2 (8/8) | 412±49 (6/6) | 105±5 (7/7) |
| 3 SSBP/1 | A136/V136 | 133±1 (15/15) | 367±10 (15/15) | |
| 2 CH1641 | A136/V136 | >564 (0/6) | 310±21 (6/6) | |
1
The number of mice developing clinical signs of prion disease divided by the original number of inoculated mice is shown in parentheses.
2
Inoculations performed in Telling lab.
3
Inoculations performed in Hunter lab.