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. 2013 Aug 16;41(20):9284–9295. doi: 10.1093/nar/gkt736

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Replication-dependent histone H2A gene expression in healthy individuals and CLL patients. Real time PCR assays were used to measure the abundance of the indicated histone H2A genes in either healthy individuals or CLL patients (N = 129). The relative expression of each isoform was determined by normalizing the PCR reactions to a control reaction that contained an equal amount of each H2A target cloned into a vector (50 fg each). H2A isoforms showing a significant change in abundance in CLL patients (P < 0.01) are indicated by an asterisk.