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. 2013 Aug 16;41(20):9284–9295. doi: 10.1093/nar/gkt736

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The 5′ UTR of HIST1H2AC is a regulatory element. (A) The 5′ UTR of each of the indicated H2A isoforms was cloned upstream of a luciferase reporter construct. Each construct was transfected into the indicated cell lines (with a renilla reporter for normalization) and luciferase levels determined by fluorescence. (B) Luciferase levels were determined as in (A) using constructs that contained either the wild type HIST1H2AC 5′ UTR (1C) or a scrambled version that contains the same base composition but in a random order (scramble).