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H2A 1C and H2A 1B/E share a common amino acid change. (A) Protein sequence alignment of H2A, H2A 1C and H2A 1B/E. Positions of identity are marked with an asterisk. Positions of divergence are highlighted in red. (B) The crystal structure of the nucleosome with residue 99 of histone H2A shown in yellow as a space-filling model.
