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. 2013 Aug 9;41(20):9209–9217. doi: 10.1093/nar/gkt683

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Degree distribution and evolutionary conservation within biological networks. The (A) protein interaction and (B) perturbation sensitivity networks are both scale-free with approximate exponents of 2.48 (γ_PPI) and 2.24 (γ_PSN), respectively. (C and D) The three-dimensional plots demonstrate that the two distinct networks are reciprocally intertwined to constitute a curved surface. Nodes are coded with different colors according to node degrees (K_PPI and K_PSN). Scatter plots between the node degrees (K_PPI and K_PSN) and (E) the protein evolutionary rate (dN/dS) and (F) the CAI demonstrate that hubs of both networks are under high evolutionary selection pressure.