Table 1. Survival and liver pathology in T. brucei WT- and TbKHC1 KO- infected mice.
Mice | Survival time (days, Mean ± SEM) | # animals tested | ALT (day 30 p.i.) (U/ml, Mean ± SEM) | # animals tested | ||
WT | TbKHC1 KO | WT | TbKHC1 KO | |||
D-Name treated | 42±6.1 | 79±10* | 11 | 753±95 | 80±69* | 12 |
L-Name treated | 45±5.1 | 46±5.6£ | 15 | 344±120£ | 216±51£ | 12 |
iNOS control | 42±8.0 | 83±15* | 6 | 618±124 | 110±69* | 6 |
iNOS KO | 38±14 | 42±6.1£ | 6 | 494±99 | 545±53£ | 6 |
Untreated | 42±9.0 | 66±12* | 24 | 783±65 | 94±79* | 15 |
L-Ornithine treated | 40±6.9 | 46±3.9£ | 12 | 649±123 | 325±45£ | 12 |
Arg1 controla | 35±4.8 | 74±10* | 12 | 808±316 | 195±177* | 4 |
LysM cre Arg1 KOb | 37±4.4 | 71±13* | 7 | 852±142 | 270±146* | 4 |
Tie2 cre Arg1 KOc | 39±7.6 | 76±9.5* | 8 | 1130±295 | 160±80* | 4 |
MMR control | 37±2.3 | 69±18* | 6 | 555±234 | 193±173 | 6 |
MMR KO | 43±11 | 59±11 | 6 | 558±111 | 145±114* | 6 |
SIGN-R1 control | 38±10 | 81±18* | 9 | 1010±300 | 270±10* | 6 |
SIGN-R1 KO | 29±6.0 | 95±12 | 13 | 745±187 | 360±50£ | 6 |
Arg1 lox/lox mice;
LysM cre Arg1 -/lox mice;
Tie2 cre Arg1 -/lox mice.
p<0.05 comparing TbKHC1 KO- and WT- infected mice ;
p<0.05 comparing treated and control treated infected mice.