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. 2013 Oct 31;9(10):e1003731. doi: 10.1371/journal.ppat.1003731

Table 1. Survival and liver pathology in T. brucei WT- and TbKHC1 KO- infected mice.

Mice Survival time (days, Mean ± SEM) # animals tested ALT (day 30 p.i.) (U/ml, Mean ± SEM) # animals tested
WT TbKHC1 KO WT TbKHC1 KO
D-Name treated 42±6.1 79±10* 11 753±95 80±69* 12
L-Name treated 45±5.1 46±5.6£ 15 344±120£ 216±51£ 12
iNOS control 42±8.0 83±15* 6 618±124 110±69* 6
iNOS KO 38±14 42±6.1£ 6 494±99 545±53£ 6
Untreated 42±9.0 66±12* 24 783±65 94±79* 15
L-Ornithine treated 40±6.9 46±3.9£ 12 649±123 325±45£ 12
Arg1 controla 35±4.8 74±10* 12 808±316 195±177* 4
LysM cre Arg1 KOb 37±4.4 71±13* 7 852±142 270±146* 4
Tie2 cre Arg1 KOc 39±7.6 76±9.5* 8 1130±295 160±80* 4
MMR control 37±2.3 69±18* 6 555±234 193±173 6
MMR KO 43±11 59±11 6 558±111 145±114* 6
SIGN-R1 control 38±10 81±18* 9 1010±300 270±10* 6
SIGN-R1 KO 29±6.0 95±12 13 745±187 360±50£ 6
a

Arg1 lox/lox mice;

b

LysM cre Arg1 -/lox mice;

c

Tie2 cre Arg1 -/lox mice.

*

p<0.05 comparing TbKHC1 KO- and WT- infected mice ;

£

p<0.05 comparing treated and control treated infected mice.