Table 1.

A sample pharmacogenomics use case

Use Case

Lauren is a physician in an outpatient clinic. She receives a pharmacogenomics test result from the Pathology lab for one of her patients. The result states that the patient has the genotype CYP2C19*2/*2. Lauren wants to know quickly what that means, and what the implications are for her patient, specifically the drugs the patient is currently taking. She would like to know if she should switch the patient to any new drugs, or change the dosage.

Abstract Query

For each drug ?d taken by patient with genotype ?g, identify recommendations for ?d, including suggested dosage changes ?c and/or recommended alternative medication ?e.