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. 2013 Nov 1;4:316. doi: 10.3389/fphys.2013.00316

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Copyright © 2013 Honasoge and Sontheimer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of pH-dependent physiology in solid tumors. (1) Radiation efficacy. (2) Salt water flux via K⁺, Cl⁻, and H₂O channels. (3) Downstream expression patterns of tumorigenic genes. (4) Mislocalization of cyclin D1 and disruption of the cell cycle. (5) Ca²⁺ permeation through ion channels (ASIC, P2X, TRP) and subsequent downstream effects. (6) Metabolic enzyme activity. (7) H⁺-coupled lactate efflux. (8) Vesicular fusion and protease enzymatic activity. (9) Interaction with the extracellular matrix. (10) Distribution of weak acids/bases.