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. 2013 Nov;183(5):1498–1507. doi: 10.1016/j.ajpath.2013.07.019

Figure 2.

Figure 2

Effect of IL-17A neutralization on hepatic accumulation of macrophages in the liver after BDL. Mice were treated with either an anti–IL-17A antibody or isotype control and then were subjected to BDL or sham operation. Nine days after surgery, F4/80-positive macrophages were identified in the liver by immunostaining in control IgG BDL mice (A) and in anti–IL-17A antibody BDL mice (B). In addition, isotype control BDL livers (C) and anti–IL-17A antibody BDL livers (D) were stained for CD68-positive macrophages. Scale bars: 100 μm. E and F: The area of positive staining was then quantified in sections of liver and expressed as a fraction of the total area. ∗P < 0.05 compared with sham-operated control mice. Data are given as means ± SEM.