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Model depicting replisome disassembly by RNF4 and PLK1 in the absence of ATR. In the absence of sufficient ATR expression, RNF4 and PLK1 become aberrantly active and function in the disengagement of replisome components from the fork. Replisome ubiquitination and removal may foster DNA processing, such as fork reversal and SLX4-dependent cleavage into DSBs.
