Skip to main content
. 2000 Dec 1;106(11):1399–1407. doi: 10.1172/JCI10536

Figure 7.

Figure 7

NEP effect on FAK-mediated cell migration. Neuropeptides such as bombesin and ET-1 promote the association of cSrc with FAK, resulting in phosphorylation of FAK at multiple sites including Tyr 577 and Tyr 925. NEP catalytically inactivates these neuropeptides and inhibits neuropeptide-induced, FAK-mediated cell migration. PI3-K also associates with FAK in focal contacts which may further activate FAK–mediated cell migration. NEP complexes with phosphorylated Lyn and binds the p85 subunit of PI3-K, competitively inhibiting the association of p85 with FAK, resulting in decreased FAK-mediated cell migration. GPI-AP, GPI-anchored protein.