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. 2013 Nov;183(5):1559–1570. doi: 10.1016/j.ajpath.2013.07.016

Figure 3.

Figure 3

Lung epithelial cell-derived collagen I inhibits sustained lung inflammation. A: Survival of littermate control (white circles; n = 25) and SCcol (black circles; n = 18) mice after bleomycin. SCcol mice have a trend toward less survival. B and C: BAL from control (white bars) and SCcol (black bars) mice at 0, 7, and 14 days after bleomycin injury was analyzed for protein (B), and cell count (C) shows that SCcol and control mice have similar increases in proteins and cell count 1 week after bleomycin, whereas SCcol mice have greater persistence of protein, n = 5 to 7 per group. ∗P < 0.05 versus control bleomycin. BAL, bronchoalveolar lavage; SCcol, triple transgenic surfactant proteins-C promoter-reverse tetracycline transactivator/tetO-cytomegalovirus promoter-Cre recombinase/homozygous floxed collagen, type I, alpha 1.