Table 2.

Enriched Functional Pathways Mapping to Differentially Expressed Genes between ALI Cultures and the in Vivo Airway Epithelium

Functional Pathways∗	Adjusted P†
Metabolic pathways	8.41 × 10−76
Alzheimer disease	8.58 × 10−34
Huntington disease	1.90 × 10−33
Parkinson disease	1.69 × 10−29
Oxidative phosphorylation	2.64 × 10−26
Pathways in cancer	4.90 × 10−21
Focal adhesion	3.30 × 10−19
Protein processing in endoplasmic reticulum	8.20 × 10−19
Endocytosis	2.93 × 10−17
Tight junction	7.04 × 10−17
MAPK signaling pathway	6.18 × 10−16
Leukocyte transendothelial migration	1.64 × 10−15
Regulation of actin cytoskeleton	3.07 × 10−15
Ubiquitin-mediated proteolysis	2.05 × 10−14
Adherens junction	2.05 × 10−14

Only the top 15 pathways are listed here; the full list appears in Supplemental Table S4.

^∗Differentially expressed genes (q < 0.001) were used to determine enriched pathways based on the KEGG database.

^†Benjamini–Hochberg adjustment.