Table 1. Summary of the principal simulations.

Simulation	Description	Duration
tal-sol-AT	talin in water; AT-MD	2×0.1 µs
tal-h2F0-CG	talin association with an anionic bilayer; CG-MD	5×1.5 µs
tal-h2F0-AT	talin association with an anionic bilayer; AT-MD	3×45
αβ-talh2-CG	αβ TM + talin in a bilayer; CG-MD	5×4 µs
αβ-talh2o-AT	αβ TM + talin in a bilayer; AT-MD	1.0 µs

This table provides of the principal simulations; further details of these and of all other simulations are provides in Supporting Information Tables S1 and S2 and in Fig. 2.