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. 2013 Sep 12;288(44):31592–31601. doi: 10.1074/jbc.M113.503300

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — The influence of cysteine substitutions upon the single-channel conductance (γ) of the 5-HT₃A(QDA) receptor. The bar graph summarizes the effect of individual replacement of residues 426–441 of the 5-HT₃A(QDA) subunit by cysteine. Data are reported as the mean percentage change in γ caused by each mutation, with the appropriate alanine substituted 5-HT₃A(QDA) receptor construct acting as control. Statistical analysis was performed by comparing the raw values of γ for the cysteine- and alanine-substituted 5-HT₃A(QDA) receptor constructs. The inset traces are single-channel events recorded from excised outside-out patches expressing either (top) 5-HT₃A(QDA) receptors (control) or (bottom) 5-HT₃A(QCA) receptors (named D436C in the graph).