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LfcinB induces IL-11 expression in human articular chondrocytes. A, chondrocytes were incubated with LfcinB (50 and 100 μg/ml) for 24 h. Transcripts of IL-11 were quantified by qPCR. B, the abundance of intracellular and extracellular IL-11 was analyzed by immunoblotting using cell lysates and conditioned media, respectively. C, chondrocytes were stimulated with LfcinB (100 μg/ml) for 24, 48, and 72 h. IL-11 mRNA expression was measured by qPCR. **, p < 0.01; ***, p < 0.001.
