Table 2: Body of Evidence Examined According to Study Design.
| Study Design | Number of Eligible Studies |
|---|---|
| RCT Studiesa | |
| Systematic review of RCTs | |
| Large RCT | 4 |
| Small RCT | |
| Observational Studiesb | |
| Systematic review of non-RCTs with contemporaneous controls | |
| Non-RCT with contemporaneous controls | 2 |
| Systematic review of non-RCTs with historical controls | |
| Non-RCT with historical controls | 1 |
| Database, registry, or cross-sectional study | |
| Case series | |
| Retrospective review, modelling | 4 |
| Studies presented at an international conference | |
| Expert opinion | |
| Total | 11 |
Abbreviation: RCT, randomized controlled trial.
a
Includes 2 cluster RCTs.
b
Includes 3 studies that are self-identified as controlled trials, but methodology is that of observational studies.