Table 3.
Selected Risk Factors for Severe Disease
| Risk Factor | Mild-Moderatea | Severe | Univariate OR (95% CI) | P Value | Multivariate OR (95% CI) | P Value |
|---|---|---|---|---|---|---|
| Transplant typeb | ||||||
| Heart | 11/105; 10% | 3/43; 7% | 0.71 (.18–2.72) | .76 | ||
| Liver | 15/105; 14% | 9/43; 21% | 1.59 (.63–3.90) | .32 | ||
| Renal | 56/105; 53% | 21/43; 49% | 0.84 (.41–1.70) | .62 | ||
| Pancreas | 1/105; 1% | 2/43; 5% | 5.07 (.56–45.9) | .20 | ||
| Renal/pancreas | 17/105; 16% | 5/43; 12% | 0.68 (.23–1.98) | .48 | ||
| Lung | 5/105; 5% | 3/43; 7% | 1.50 (.34–6.55) | .59 | ||
| Immunosuppression | ||||||
| Calcineurin inhibitor | 99/108; 92% | 40/43; 93% | 1.21 (.28–7.30) | .99 | ||
| Mycophenolate | 83/108; 76% | 39/43; 92% | 2.94 (1.00–8.71) | .05 | 9.41 (1.27–66.1) | .028 |
| Corticosteroid | 86/108; 80% | 28/43; 65% | 0.48 (.22–1.04) | .06 | ||
| Organ involvement | ||||||
| Pulmonary | 85/108; 79% | 37/43; 86% | 2.94 (.99–8.71) | .07 | ||
| Disseminated | 83/108; 77% | 39/43; 91% | 0.37 (.13–1.05) | .06 | ||
| Bone marrow | 23/108; 21% | 16/43; 37% | 2.20 (1.02–4.70) | .04 | 2.62 (.81–12.2) | .098 |
| Liver | 19/108; 18% | 8/43; 19% | 1.07 (.43–2.68) | .89 | ||
| Spleen | 10/108; 9% | 9/43; 21% | 2.50 (.99–6.78) | .06 | ||
| Skin | 4/108; 4% | 1/43; 2% | 0.62 (.07–5.63) | .56 | ||
| Gastrointestinal | 13/108; 12% | 3/43; 7% | 0.50 (.15–2.00) | .56 | ||
| Central nervous system | 6/108; 6% | 4/43; 9% | 1.74 (.47–6.45) | .76 | ||
| Fungemia | 28/57; 49% | 27/30; 90% | 9.32 (2.72–32.1) | .001 | 5.40 (1.24–23.4) | .024 |
| Median urine antigen, ng/mL (No. sent, range) | 10.8 (101c; 0 to >19) | 19 (40c; 0 to >19) | 1.11 (1.05–1.18) | .001 | 1.029 (.87–1.22) | .73 |
| Urine antigen >19 ng/mL | 31% | 56% | 2.9 (1.30–6.20) | .01 | 5.86 (.62–55.7) | .124 |
| Median serum antigen, ng/mL (No. sent, range) | 11.6 (37c; 3.5 to >19) | 10.2 (13c; 0 to >19) | 1.016 (.97–1.07) | .40 | ||
Abbreviations: CI, confidence interval; ng, nanograms; OR, odds ratio.
a Severity of 1 case could not be classified.
b One small bowel and 2 multiorgan nonrenal/pancreas transplants not included.
c No. of patients in whom results of the respective test were available.