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. 2013 Nov 1;4:308. doi: 10.3389/fphys.2013.00308

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Copyright © 2013 Chaussain, Boukpessi, Khaddam, Tjaderhane, George and Menashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early dentin repair in an injured rat pulp model induced by the implantation of C-DMP1 peptide mimicking an MMP2 cleaved peptide of DMP1.Beads soaked with c-DMP1 polypeptide were implanted in the injured pulp of young rats. At day 7, osteopontin (OPN) immunohistochemistry shows strong immunoreactivity of reparative structures (arrowheads) observed in the injured pulp resembling mineralization foci (Mckee et al., 1993). Bridge formation at longer time points may partly result from growth and spreading of these mineralization foci. At higher magnification (right panel), immunopositive cells (arrows) are observed adjacent to the reparative structures.p: pulp; rd: reactionary dentin; d: dentin.