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. 2013 Nov;23(11):1763–1773. doi: 10.1101/gr.156240.113

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© 2013 Giannuzzi et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 5. — Model of the evolution of ape chromosomes 14 and 15. The picture highlights the centromere repositioning on chromosome 15, the neocentromere formation on chromosome 14, the sequence duplications from and to the novel pericentromeric and subtelomeric regions, and the acquisition of telomeric repeats, rDNA, and alphoid DNA that occurred in the last 25 million years of human evolution. The pericentric inversions in the chimpanzee and gorilla lineages caused the loss of the rDNA from the inverted chromosomes.