Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Nov;23(11):1862–1873. doi: 10.1101/gr.155697.113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Ju et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

PMC Copyright notice

Figure 3. — Evaluation of podocyte-specific genes based on qualified Human Protein Atlas (HPA) staining images. (A) HPA images demonstrate podocyte-specific pattern of positive standard markers and predicted genes. Staining pattern of positive standard markers: podocyte-specific in kidney (I): nephrin (NPHS1) and podocyte-specific in glomerulus: (II) SYNPO and (III) CD2AP. Exemplary staining patterns for de novo nanodissection predicted proteins (IV–IX): (IV) FGF1; (V) ARHGAP28; (VI) PRKAR2B; (VII) PCOLCE2; (VIII) GJA1; and (IX) ZDHHC6. (B) HPA-based distribution intrarenal protein staining pattern in random gene set, nanodissection-identified gene set, and the murine experimental approach-derived gene set: The in silico nanodissection approach (65%) significantly outperforms a random set of genes (12%) and the ex vivo murine experimental approach (23%) for identifying podocyte-specific genes. Gray bars show the proportion of genes with exclusively podoctye-specific staining within the kidney, and black bars show the proportion of genes with exclusively podocyte-specific staining within the glomerulus.