Table 3a.

Mean DICE coefficients and results from the repeated-measures ANOVA using the factors Group (no-lesion, small-lesion, medium-lesion, and large-lesion), Normalization (Standard Normalization, Unified Segmentation, New Segmentation) and Skull (deskulled, skulled images) separately for whole-brain, gray-matter and white matter. Only significant effects with their corresponding mean DICE coefficients (standard error is given in brackets) are given.

Whole-brain analysis:

Main effect Skull: F = 1141.209; df = 1,36; p < 0.000

Deskulled: 0.857 (0.002); skulled: 0.786 (0.002)

Main effect Group: F = 5.258; df = 3,36; p < 0.004

No-lesion: 0.830 (0.003); small: 0.820 (0.003); medium: 0.819 (0.003); large: 0.817 (0.003)

Interaction effect Skull × Group: F = 8.590; df = 3,36; p < 0.000

Deskulled: No-lesion: 0.875 (0.005); small: 0.853 (0.005); medium: 0.851 (0.005); large: 0.849 (0.005)  Skulled: No-lesion: 0.786 (0.001); small: 0.788 (0.001); medium: 0.787 (0.001); large: 0.785 (0.001)

Gray-matter analysis:

Main effect Skull: F = 127.169; df = 1,36; p < 0.000

Deskulled: 0.857 (0.002); skulled: 0.786 (0.002)

Main effect Normalization: F = 7.207; df = 2,72; p < 0.001

Normalization: 0.747 (0.004); Unified Segmentation: 0.764 (0.008); New Segment: 0.779 (0.002)

Interaction effect Normalization × Skull: F = 7.859; df = 2,72; p < 0.001

Deskulled: Normalization: 0.771 (0.005); Unified Segmentation: 0.781 (0.09); New Segmentation: 0.788 (0.004)  Skulled: Normalization: 0.723 (0.004); Unified Segmentation: 0.746 (0.007); New Segmentation: 0.752 (0.002)

Interaction effect Normalization × Skull × Group: F = 3.387; df = 6,36; p > 0.005

See Table 3b for details on mean DICE coefficients.

White-matter analysis:

Main effect Skull: F = 234.189; df = 1,36; p < 0.000

Deskulled: 0.682 (0.003); skulled: 0.653 (0.003)

Interaction Normalization × Skull: F = 14.312; df = 2,72; p < 0.000

Deskulled: Normalization: 0.679 (0.002); Unified Segmentation: 0.679 (0.007); New Segmentation: 0.687 (0.004)  Skulled: Normalization: 0.642 (0.003); Unified Segmentation: 0.656 (0.006); New Segmentation: 0.661 (0.003)