Figure 1.

Cytotoxic effect of bozepinib and combined bozepinib/IFNα therapy. (A) Chemical structure of bozepinib. (B) MCF-7, HCT-116, and RKO cell lines treated with increasing amounts of bozepinib alone (circle) or in combination with 50 IU/mL IFNα (square) for 6 days as described in the Materials and methods section. Cell lines have been defined in material and methods section. The curve for cell survival is represented as a percentage compared to mock-treated cells. Values shown represent the mean of triplicate determinations calculated from a single experiment. Experiments were repeated at least three times.

Abbreviation: IFNα, interferon-alpha.