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. 2013 Oct 31;8(10):e78896. doi: 10.1371/journal.pone.0078896

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© 2013 Xie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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We name the functional sets that linked by DPGs as interacted sets, and the linkage is based on the situation that one gene of a DPG pair is annotated for one function and the other for another functions. The interaction rate is related to the linked DPGs number and the set size. Interaction rate >7% is chosen to cover more functional sets. The edge color depends on the DPGs number that linked two adjacent sets, and the edge width depends on the interaction rate between two sets. Module 1 is related to histone and DNA packaging. Module 2 is related to regulation of cell cycle, gene expression, energy and some other functions. Module 3 is related to cancer signaling.