Table 2. AUC (0-t) values of tissues and tissue/plasma ratios of BBR and its metabolites.
| Tissues | liver | kidney | muscle | lung | brain | heart | pancreas | fat |
| BBR AUC (0-t) of tissues (ng/mL×h) | 728.6±188.1a | 362.7±63.5a | 84.2±15.3 | 66.0±10.2 | 47.8±6.4 | 47.4±5.6 | 12.0±2.0 | 6.8±1.1 |
| Metabolites AUC(0-t) of tissues (ng/mL×h) | 2103.5±347.2b | 161.4±29.8 | 6.2±1.9 | 31.4±7.3 | ND* | 0.6±0.18 | 0.3±0.03 | ND |
| BBR AUC (0-t) of tissues/BBR AUC (0-t) of plasma | 10.17±2.7 | 5.06±0.9 | 1.18±0.3 | 0.92±0.2 | 0.67±0.1 | 0.66±0.1 | 0.17±0.03 | 0.09±0.02 |
| Metabolites AUC(0-t) of tissues/BBR AUC (0-t) of plasma | 29.36±4.9 | 2.25±0.5 | 0.09±0.03 | 0.44±0.1 | ND | 0.008±0.01 | 0.004±0.0003 | ND |
*
ND: not detected. Data are represented as mean ±S.D. (n = 6). One-way ANOVA: BBR AUC (0-t) or Metabolites AUC (0-t) of tissues were compared with control (AUC(0-t) of plasma), which was 71.65 (ng/mL×h).
a
p<0.0001(which means “***” in the result shown by GraphPad Prism® 5 software), compared BBR AUC (0-t) of tissues with BBR AUC(0-t) of plasma;
b
p<0.0001, compared metabolites AUC (0-t) of tissues with BBR AUC (0-t) of plasma.