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. 2013 Oct 31;8(10):e77969. doi: 10.1371/journal.pone.0077969

Table 2. AUC (0-t) values of tissues and tissue/plasma ratios of BBR and its metabolites.

Tissues liver kidney muscle lung brain heart pancreas fat
BBR AUC (0-t) of tissues (ng/mL×h) 728.6±188.1a 362.7±63.5a 84.2±15.3 66.0±10.2 47.8±6.4 47.4±5.6 12.0±2.0 6.8±1.1
Metabolites AUC(0-t) of tissues (ng/mL×h) 2103.5±347.2b 161.4±29.8 6.2±1.9 31.4±7.3 ND* 0.6±0.18 0.3±0.03 ND
BBR AUC (0-t) of tissues/BBR AUC (0-t) of plasma 10.17±2.7 5.06±0.9 1.18±0.3 0.92±0.2 0.67±0.1 0.66±0.1 0.17±0.03 0.09±0.02
Metabolites AUC(0-t) of tissues/BBR AUC (0-t) of plasma 29.36±4.9 2.25±0.5 0.09±0.03 0.44±0.1 ND 0.008±0.01 0.004±0.0003 ND
*

ND: not detected. Data are represented as mean ±S.D. (n = 6). One-way ANOVA: BBR AUC (0-t) or Metabolites AUC (0-t) of tissues were compared with control (AUC(0-t) of plasma), which was 71.65 (ng/mL×h).

a

p<0.0001(which means “***” in the result shown by GraphPad Prism® 5 software), compared BBR AUC (0-t) of tissues with BBR AUC(0-t) of plasma;

b

p<0.0001, compared metabolites AUC (0-t) of tissues with BBR AUC (0-t) of plasma.