Table 1. Mutations in nbs1 alleles.
Allele | Mutation | Location (bp) | Effect on Protein |
---|---|---|---|
nbs1-1 | A→G | 1235 | In intron splice site, early truncation after amino acid 400 |
nbs1-2 | CC→TT | 188–189 | Serine → phenylalanine at amino acid 43 |
nbs1-3 | C→T | 2126 | Early truncation after amino acid 570 |
nbs1-4 | C→T | 2126 | Early truncation after amino acid 570 |
nbs1-5 | GGCACT→GGTA-T | 1072–1074 | Early truncation after amino acid 288 |