Table 1. Metabolites and lipids whose levels are most significantly driven by expression of neighboring genes in a bi-partite genome-scale metabolic map.

MET/LIP	p.BH	n.MetMap.linked	n.PCC.sig	n.linkedANDsig
ERGOST	7.97E-08	102	76	9
PEP	4.56E-06	293	80	7
LNST	9.69E-06	105	98	7
SUCC	4.68E-05	176	5	1
MAL	4.68E-05	244	11	2
EPST	5.91E-05	69	4	0
DMZYMST	7.83E-05	70	55	2
PINS181	0.000236	203	29	2
NADPH	0.000761	480	0	0
NADP	0.000926	503	0	0
PINS160	0.00227	203	38	0
PINSS181	0.00247	172	33	1
ALA	0.00247	336	11	4
PINS	0.00304	203	56	2
SE161	0.00304	54	20	1
PYRxt	0.00332	67	32	1
TAG100	0.00401	60	58	2
PROxt	0.00401	165	18	1
TAG140	0.00401	60	91	3
LYS	0.00405	336	5	1
ZYMST	0.00521	74	0	0
PYR	0.00729	369	22	3

MET/LIP: metabolites/lipids; p.BH, P ≤ 0.01, Benjamini Hochberg P value adjustment; n.MetMap.linked, number of genes linked to the specified metabolite in the genome-scale metabolic map; n.PCC.sig, number of genes significantly correlated to the specified metabolite (P ≤ 0.01 Bonferroni P value adjustment); n.linkedANDsig, number of metabolites both linked in the genome-scale metabolic map and significantly correlated (i.e., the overlap between the previous two columns); ERGOST, ergosterol; PEP, phosphoenolpyruvate; LNST, lanosterol; SUCC, succinate; MAL, malate; EPST, episterol; DMZYMST, 4,4-dimethylzymosterol; PINS181, 18:1 in phosphatidylinositol; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); NADP, nicotinamide adenine dinucleotide phosphate; PINS160, 16:0 in phosphatidylinositol; PINSS181, 18:1 (Δ⁹) in phosphatidylinositol; ALA, alanine; PINS, phosphatidylinositol; SE161, steryl ester 16:1; PYRxt, pyruvate (extracellular); TAG100, 10:0 in triacylglycerol; PROxt, proline (extracellular); TAG140, 14:0 in triacylglycerol; LYS, lysine; ZYMST, zymosterol; and PYR, pyruvate.