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. 2013 Nov 1;3(11):2059–2067. doi: 10.1534/g3.113.007484

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Copyright © 2013 Canfield et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Core-region haplotypes defined using 16 SNPs. (A) Diagram showing relationships between common haplotypes C1 through C11. SNPs that differ between adjacent haplotypes are labeled by nickname (SNP c1 through c16, keyed to Table S2). Haplotype C1 contains ancestral alleles for each SNP in this series. Haplotype C11 carries the derived Thr-111 allele of SLC24A5 (rs1426654, SNP c11). The only duplicated transition in this diagram is for SNP c1 (rs1834640). Note that analysis of additional SNPs reveals cases in which adjacent haplotypes in the diagram do not have ancestor-descendent relationships (compare Figure 4). (B) Histograms showing the distribution of haplotypes in several HapMap populations. The three East Asian populations are combined, as are CEU and TSI. Indeterminate C2/C3 in TSI indicated. MEX and ASW are not depicted. The frequency scale is split at 0.2.