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. 2013 Nov 1;3(11):2059–2067. doi: 10.1534/g3.113.007484

Table 3. A111T date estimation using 1000 Genomes Project data.

Population Chromosomes Difference Total Effective Sample Size Date, kya (95% Confidence Limits)
Combined 1013 822 19 7.8 (4.8−12.2)
CEU 165 110 13 6.4 (3.4−11.4)
GBR 178 136 14 7.4 (4.1−12.4)
FIN 180 160 10 8.6 (4.5−15.1)
TSI 193 105 18 5.2 (2.9−9.0)
IBS 28 24 9 8.3 (4.2−15.0)
PUR+MXL+CLM 231 249 16a 10.4 (6.5−15.8)

Human-chimpanzee alignment contains 1227 differences in aligned length of 125,531, of total 127,419 nt in C+D region. When a divergence date of 6 million years ago is used, this corresponds to a per-site mutation rate of 8.1 × 10−10 year-1. Dates shown are not corrected for undercounting of rare polymorphisms. For combined C11 sample, distribution of variants suggests that tabulated dates should be multiplied by a factor of 1.58. kya, thousand years ago.

a

Estimated effective samples sizes ranged from 9-13 for individual admixed New World samples.